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Variability in the Measure of Total Ascorbic Acid Utilization by the Human^1,2,3,

One Figure

College of Home Economics and Agricultural Experiment Station The Pennsylvania State University, State College

The two factors of variability studied have been an outgrowth of an investigation of total ascorbic acid utilization by the human. The factors are the carry-over effect of previous intake of total ascorbic acid on subsequent data and the effect of the same amount of a test dose of ascorbic acid given either at a single time or divided by an interval of time. In addition, the sensitivity of blood plasma and urine measurements as a means to differentiate changes in ascorbic acid intake has been studied. Total ascorbic acid measurements of the blood plasma and of 24-hour urine returns were the measures.

From the data obtained under the conditions of these experiments it is concluded that:

1. The carry-over effect of both high and low intakes of total ascorbic acid is still evident in the blood plasma for at least 23 days after transfer to a new intake level. The excretion of total ascorbic acid appears to adjust more quickly than does the blood plasma level.

2. There are no significant differences in blood plasma or urinary total ascorbic acid values when the same amount of the vitamin, either 75 or 150 mg, is ingested as a single or divided intake.

3. Blood plasma levels and 24-hour urine returns of total ascorbic acid are demonstrated to differentiate between intakes of 60 and 75 mg for 8 subjects at each level (significant 1% level). Differentiation is suggested by as few as three subjects at each level (significant 5% level).

² Research Contribution no. 123, College of Home Economics.

³ Portions of these data were obtained from research supported in part by the United States Department of Agriculture through a contract sponsored by the Human Nutrition Branch of the Agricultural Research Service.

Manuscript received 26 May 1954.