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Journal of Nutrition Vol. 54 No. 2 October 1954, pp. 209-214
Copyright © 1954 by American Society for Nutrition
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Organ Weights and Obesity in Mice1

Samuel H. Waxler and Marilyn Enger

Department of Pharmacology and Therapeutics, Standfard University School of Medicine, San Francisco, California

1. The organs of obese animals tend to be heavier than those of control mice, and this increase in weight is apparent in the wet, dry and defatted state. This increase in organ weight of obese animals cannot be accounted for by adipose tissue alone.
2. Mice which were made experimentally obese were subsequently reduced to the weight of controls. These animals were then maintained by pair-feeding at the weight level of their controls. The organ weights of these reduced animals were of the same order of magnitude as those of the controls.

1 This investigation was supported by a grant-in-aid from the National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Maryland.

Manuscript received 9 November 1953.




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