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Effect of Varying the Intake of Calcium Pantothenate of Rats during Pregnancy

II. Histological and Histochemical Studies of the Liver, Adrenal, Duodenum and Tibia of the Young at Birth^{1 ,2}

Four Figures

Nutrition Laboratory, Home Economics Research Department, Iowa Agricultural Experiment Station, and Department of Veterinary Anatomy, Iowa State College, Ames

Histological and histochemical studies of the liver, adrenal, duodenum and tibia were made on newborn rats whose dams were fed several levels of pantothenic acid during reproduction. Tissues studied to date reveal little if any evidence of tissue change in the newborn rats except in the case of the adrenals which exhibited a decreased alkaline phosphatase reaction for the most deficient group of animals.

It appeared that the young of pantothenic acid-deficient females were normal at birth insofar as the structure of the 4 tissues studied was concerned. It would appear that whatever pathology may be produced in the fetal tissues by these dietary regimes is evidenced in the prenatal life of the fetuses thus contributing to early fetal resorptions.

² Financial support from the Department of Health Education and Welfare, Public Health Service, National Institutes of Health (G-3198) is gratefully acknowledged.

³ Present address: Department of Home Economics, University of California, Davis, California.

Manuscript received 1 March 1954.