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Journal of Nutrition Vol. 53 No. 4 August 1954, pp. 533-541
Copyright © 1954 by American Society for Nutrition
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Partial Starvation and Alcohol Metabolism

An Example of Adaptation to Undernutrition1

Three Figures

J. J. Vitale, June Nay and D. M. Hegsted

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Adult rats were made to lose weight either rapidly or slowly by the restriction of their food intake. The ability to oxidize ethanol as measured by the excretion of C14O2 after giving ethanol-1-C14 decreased markedly while the animals were losing weight. However, as soon as the weight of the animals became stationary, the ability to oxidize alcohol returned to normal. The results are interpreted in the light of previous studies upon liver changes during starvation and protein deficiency. The study appears to provide a clear-cut example of adaptation to undernutrition.

1 Supported in part by grants-in-aid from National Vitamin Foundation, New York; Clayton Foundation for Research, Pasadena, California; J. M. Kaplan Fund, Inc., New York; and Eli Lilly and Company, Indianapolis, Indiana.

Manuscript received 15 February 1954.




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