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Phenylalanine and Tyrosine Utilization in Normal and Phenylalanine-Deficient Young Mice¹

Two Figures

Department of Biology, Brookhaven National Laboratory, Upton, New York

Young mice were maintained on normal or phenylalanine-deficient diets in which tyrosine and other amino acids were adequately supplied. Meals of similar composition but containing uniformly labeled C¹⁴ L-phenylalanine or C¹⁴ L-tyrosine were fed, expired C¹⁴O₂ was collected and measured for 30 minutes, and the animals were then killed. Tyrosine and phenylalanine (as phenylethylamine hydrochloride) were isolated from the liver proteins and their C¹⁴ contents were determined.

Mice fed the phenylalanine-deficient diet converted less of the absorbed phenylalanine to liver protein tyrosine and less to CO₂ than did the animals fed the diet containing enough phenylalanine for normal growth.

Absorbed C¹⁴ L-tyrosine was not converted to liver protein phenylalanine by either the normal or phenylalanine-deficient mouse.

² On leave from the Department of Poultry Husbandry, University of California, Berkeley.

Manuscript received 17 September 1953.