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Some Effects of Excess Molybdenum on the Nutrition of the Rat

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U. S. Plant, Soil and Nutrition Laboratory, Bureau of Plant Industry, Soils and Agricultural Engineering, A.R.A., U. S. Department of Agriculture, Ithaca, New York, and the Department of Biochemistry and Nutrition, Cornell University, Ithaca

1. The addition of methionine to the diet markedly prevented the harmful effects of excess molybdenum.

2. The relationship between copper and molybdenum was again demonstrated, as supplementary copper prevented approximately one-third of the deleterious effect of molybdenum at the mineral levels used in these studies.

3. Supplementation of the diet with both meth onine and copper was no more efficacious in counteracting the toxicity than the use of methionine only.

4. Vitamin B₁₂ alleviated molybdenum toxicity in one experiment reported. This effect could not be repeated. Reasons for the differences in results obtained are suggested.

5. Possible explanations for the efficiency of methionine in counteracting the toxic effects of dietary molybdenum have been presented.