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The Effect of Fat Level of the Diet on General Nutrition

XI. The Protective Effect of Varying Levels of Ethyl Linoleate Against Multiple Sublethal Doses of X-Irradiation in the Rat^1,2,3,

One Figure

Department of Biochemistry and Nutrition, School of Medicine, University of Southern California, Los Angeles

The protective effect of linoleate against x-irradiation in the rat has been confirmed.

On the basis of the average length of survival, and from comparison of the periods required for LD₂₅, LD₅₀ and LD₇₅ to be reached in male rats subjected to x-irradiation, it was demonstrated that the protective effect of ethyl linoleate became greater with increasing dosage.

The optimum dosage for protection against x-irradiation injury, in male rats, probably exceeds 100 mg per day.

² Contribution 355 of the Department of Biochemistry and Nutrition, University of Southern California.

³ The results were presented in part at the Gordon Research Conference, August 10, 1953.

Manuscript received 14 December 1953.