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Journal of Nutrition Vol. 52 No. 4 April 1954, pp. 627-636
Copyright © 1954 by American Society for Nutrition
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A Mechanism of the Vitamin-Sparing Effect of Antibiotics1

W. J. Monson, A. E. Harper, M. E. Winje and C. A. Elvehjem

Department of Biochemistry

R. A. Rhodes and W. B. Sarles

Department of Bacteriology, University of Wisconsin

The growth of chicks fed synthetic diets containing limiting amounts of folic acid was increased by supplementing the diets with antibiotics. This increase in growth was accompanied by the appearance of one or more coliforms in the ileum and duodenum contents that produced increased amounts of extracellular folic acid. This change was apparent in two days in the ileum contents of 4-week-old chicks. It was also observed that the increased folic acid production was correlated with increased liver folic acid, but there was no change in the concentration of intestinal folic acid. These results explain at least in part the mechanism by which antibiotics spare vitamins for the chick.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation.

We are indebted to Merck and Co., Rahway, N. J., for some of the crystalline, vitamins and for crystalline penicillin; to the Commercial Solvents Corporation, Terre Haute, Ind., for bacitracin; to Wilson and Co., Inc., Chicago, Ill., for gelatin; to the Abbott Laboratories, North Chicago, Ill., for haliver oil; and to E. I. DuPont de Nemours and Co., Inc., New Brunswick, N. J., for crystalline vitamin D3.

Manuscript received 30 November 1953.




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