Journal of Nutrition

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Journal of Nutrition Vol. 52 No. 4 April 1954, pp. 519-524
Copyright © 1954 by American Society for Nutrition
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Prevention of the Cholesterol Type of Fatty Livers in Mice by Dietary Dihydrocholesterol

William T. Beher and William L. Anthony

Edsel B. Ford Institute for Medical Research, Henry Ford Hospital, Detroit, Michigan

1. Increasing the cholic acid content of a diet containing cholesterol significantly increased mouse liver cholesterol and ß steroids, up to a limiting value.
2. The addition of dihydrocholesterol to diets containing cholic acid and cholesterol significantly decreased mouse liver cholesterol and ß steroids.
3. Increasing the cholic acid content of a diet containing constant amounts of dihydrocholesterol and cholesterol significantly decreased mouse liver cholesterol and ß steroids.
4. Under all conditions, total liver cholesterol and ß steroid concentrations were parallel.

Manuscript received 1 October 1953.




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