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Hepatic Necrosis Induced by Dietary Means

VIII. The Effect of Feeding a Diet Free from Fat at Successive Intervals to Groups of Weanling Rats

Department of Biochemistry, Queen's University, Kingston, Canada

A diet free from fat was fed to 5 successive groups of male weanling rats over a period of 15 months.

In the first experiment none of the rats devleoped hepatic necrosis in a period of 172 days. In all subsequent groups hepatic necrosis developed with a general trend towards an increasing incidence.

It is tentatively suggested that these results might be explained on the basis that intestinal organisms having a strong predisposing influence on the production of the lesion were inhibited in the first case and subsequently became adapted to the altered dietary conditions with the consequent production of liver necrosis.