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Unsaturated Fatty Acids and Alloxan Diabetes¹

One Figure

Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina

The influence of different diets fed during a preliminary period of one month on the toxic and diabetogenic action of alloxan was studied in male rats. Following this month-long regime, the animals were injected with alloxan and mortality was observed over a 10-day period. Immediately thereafter a 7-hour fasting glycemia was produced and measured.

High fat diets, the fat in which consisted primarily of saturated fatty acids, had a markedly protective action against the toxic and diabetogenic effects of alloxan as compared with a high carbohydrate diet.

High fat diets rich in unsaturated fatty acids had an aggravating action.

Partial hydrogenation of sunflower oil reduced the toxic and diabetogenic action of alloxan.

The administration of vitamin E to the rats fed the high oil diets had no influence on the action of alloxan.

There was a marked and direct correlation between the iodine number of the fat fed and the toxic and diabetogenic action of alloxan.

Manuscript received 20 July 1953.