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Nature of the "Vitamin A-Like Factor" in Lard

One Figure

Eastern Regional Research Laboratory, ¹ Philadelphia, Pennsylvania

Hans Kaunitz and Charles A. Slanetz

College of Physicians and Surgeons, Columbia University, ² New York, N. Y.

Biological assays on molecular distillates from lard showed that lard contains vitamin A activity equivalent to about four-tenths to two units per gram.

Chromatographic fractionation of unsaponifiables from lard and molecular distillates from lard yielded eluates which gave positive Carr-Price tests and typical vitamin A spectral curves, except in fractions having an extremely high ratio of unsaponifiables to units of vitamin A.

It is concluded that the biological vitamin A activity of lard is largely attributable to the presence of typical vitamin A. The so-called "sparing" action of lard on utilization of added vitamin A in diets is in all probability due to the presence in lard of hitherto unrecognized typical vitamin A.

² From the Department of Pathology and the Institute of Research in Animal Diseases, College of Physicians and Surgeons, Columbia University, New York, N. Y.; supported by the Williams-Waterman Fund of the Research Corporation.

Manuscript received 20 June 1953.

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				S. R. Ames and P. L. Harris Identification of the So-called "Lard Factor" as Vitamin A Science, September 3, 1954; 120(3114): 391 - 393. [PDF]