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Journal of Nutrition Vol. 51 No. 2 October 1953, pp. 273-281
Copyright © 1953 by American Society for Nutrition
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The Metabolism of Fluorine in the Bones of the Fluoride-Poisoned Rat1

Russell F. Miller and Paul H. Phillips

Department of Biochemistry, University of Wisconsin, Madison

The elimination of fluorine from the femur of the young female rat fed a fluoride-containing diet has been studied.

It was found that the total fluorine in the femur of such a young rat was reduced approximately 44% during the first 8 weeks after the period of high fluoride intake. The residual fluorine in the femur was not further reduced appreciably or changed after this initial drop at the end of 8 weeks. There-after it remained fairly constant for the additional observation period of 24 weeks. Control animals which were not fed a high fluoride ration but which subsisted on a diet containing only three to 5 p.p.m. of fluorine continued to store this element in the femur during the entire observation period of 32 weeks.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by a grant from the Aluminum Company of America, Pittsburgh, Pennsylvania, on behalf of itself and the American Smelting and Refining Co., the Kaiser Aluminum and Chemical Corporation, the Monsanto Chemical Co., the Reynolds Metal Co., the Tennessee Valley Authority, and the U. S. Steel Corporation of Delaware.

Manuscript received 16 June 1953.




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