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Journal of Nutrition Vol. 51 No. 2 October 1953, pp. 251-259
Copyright © 1953 by American Society for Nutrition
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The Effect of Mucin on the Growth of Rats Fed Simulated Human Milk1

R. M. Tomarelli, E. Linden, G. T. Durbin and F. W. Bernhart

Wyeth Laboratories Inc., Nutritional Division, Mason, Michigan

Hog gastric mucin, a potent source of a microbiological growth factor also present in human milk, when fed with a basal diet of a composition approximating that of human milk resulted in increased growth and, in some cases, increased survival time of weanling rats. The biological effect of mucin was demonstrable with a modified skim cow's milk ration, with a semi-synthetic diet composed of casein, lactose, hydrogenated cottonseed oil and salts, and with milk rations containing iodinated casein. The destruction of the microbiological growth activity of mucin by prolonged acid hydrolysis also resulted in a loss of the rat growth activity.

1 Presented before the American Institute of Nutrition, Chicago, 1953.

Manuscript received 11 May 1953.




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