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Journal of Nutrition Vol. 51 No. 1 September 1953, pp. 23-34
Copyright © 1953 by American Society for Nutrition
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Folic Acid Deficiency in the Guinea Pig1

Calvin W. Woodruff2, Sam L. Clark, Jr.3 and Edwin B. Bridgeforth

Department of Pediatrics and Division of Nutrition, Departments of Medicine and Biochemistry, Vanderbilt School of Medicine, Nashville, Tennessee

1. These studies confirm the need of the guinea pig for a dietary source of folic acid. No dietary requirement for PABA by this species could be demonstrated, but PABA was found partially to replace PGA in the diet of the guinea pig.
2. PGA deficiency in the immature guinea pig was characterized by growth failure, leukopenia, anemia and immaturity of the erythroid precursors in the bone marrow.
3. This deficiency could be produced either by the omission of PABA from a purified diet deficient in PGA or by the inclusion of both PABA and 1% sulfasuxidine.

1 Financial support from the U. S. Public Health Service, the Nutrition Foundation and the Rockefeller Foundation is gratefully acknowledged.

2 Markle Scholar in Medical Science.

3 National Research Council Fellow.

Manuscript received 1 June 1953.




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