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Effect of 3-Nitro, 4-Hydroxyphenylarsonic Acid and Arsanilic Acid on Selenium Poisoning in the Rat¹

Station Biochemistry, South Dakota Agricultural Experiment Station, South Dakota State College, College Station

1. Arsanilic acid and 3-nitro, 4-hydroxyphenylarsonic acid were found to give partial protection against chronic selenium poisoning in rats. The degree of protection increased as the levels of the two arsenicals increased. However, even at the highest levels used (arsanilic acid —0.025%; 3-nitro, 4-hydroxyphenylarsonic acid —.009%) complete protection was not observed.

2. Levels of 0.009% 3-nitro, 4-hydroxyphenylarsonic acid and 0.009 and 0.025% arsanilic acid gave no growth response with the non-seleniferous control diets used in these experiments.

² Present address: Chemistry Department, South Dakota State College.

Manuscript received 23 March 1953.