Journal of Nutrition

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Journal of Nutrition Vol. 50 No. 3 July 1953, pp. 383-393
Copyright © 1953 by American Society for Nutrition
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The Influence of Protein and Certain Amino Acids, Particularly Threonine, on the Deposition of Fat in the Liver of the Rat1

A. E. Harper2, W. J. Monson, D. A. Benton and C. A. Elvehjem

Department of Biochemistry, University of Wisconsin, Madison

The influence of protein (gelatin and additional casein), threonine, glycine, serine, glycocyamine, choline and betaine on the deposition of fat in the livers of rats fed 9% caseinsucrose rations containing adequate choline, methionine, inositol and vitamin B12 has been studied. Six per cent gelatin, 2% casein or 0.18% DL-threonine were each effective in reducing the accumulation of liver fat observed in animals receiving the basal ration. The other compounds listed reduced the accumulation of liver fat to a lesser extent under these conditions.

The possibility that enzymes concerned with fat metabolism might have been limiting in animals receiving the basal ration has been discussed, as has also the suggestion that some of these substances may participate more directly in fat metabolism. No satisfactory explanation of the results can be proposed as yet.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by grants from Swift and Company, Chicago, Illinois, the Gelatin Research Society of America, Inc., New York, N. Y., and the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation.

We are indebted to Merck and Co., Rahway, N. J., for crystalline vitamins; to Wilson and Co., Chicago, Ill., for gelatin; to the Abbott Laboratories, Chicago, Ill., for haliver oil; and to Dr. R. A. Collins of the International Minerals and Chemical Corporation, Skokie, Ill., for betaine and glycocyamine.

2 Permanent address: Department of Biochemistry, University of Alberta, Edmonton, Canada.

Manuscript received 9 March 1953.




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