Journal of Nutrition

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Journal of Nutrition Vol. 50 No. 3 July 1953, pp. 299-316
Copyright © 1953 by American Society for Nutrition
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Effects of Pantothenic Acid Deficiency on Pituitary-Adrenal Function in the Rat1

B. H. Ershoff, R. B. Alfin Slater and J. G. Gaines

Emory W. Thurston Laboratories, Los Angeles, and the Department of Biochemistry and Nutrition, University of Southern California, Los Angeles

Tests were conducted to determine the effects of pantothenic acid deficiency on the pituitary-adrenal system of the rat. Pituitary-adrenal activation following epinephrine and ACTH administration was measured by the following indices of adrenocortical activation: (1) reduction in the peripheral lymphocyte count; (2) adrenal ascorbic acid depletion; and (3) reduction in adrenal cholesterol concentration. Findings for pantothenic acid-depleted rats were contrasted to those observed for rats fed a complete ration, either ad libitum or in an amount equal to that ingested daily by rats on the pantothenate-free ration. In addition to the above indirect measurements of adrenocortical activation, tests were conducted on the capacity of pantothenic acid-depleted rats to survive following egg white intoxication (the latter has been employed as a functional test for the presence of cortisone-like hormones in the rat). No significant impairment in pituitary-adrenal function was observed in pantothenic acid-depleted rats, as judged by the above indices.

1 This paper reports research undertaken in cooperation with the Office of Naval Research and the Quartermaster Food and Container Institute for the Armed Forces. The views or conclusions contained in this report are those of the authors. They are not to be construed as necessarily reflecting the views or indorsement of the Department of the Army or the Office of Naval Research. Communication 330 from the Department of Biochemistry and Nutrition, University of Southern California.

Manuscript received 22 January 1953.




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