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The Disappearance of Radioactivity from the Tissues of Rats of Different Ages After Subcutaneous Administration of Radiovitamin B₁₂

Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Md.

Vitamin B₁₂* was injected subcutaneously at 4 different levels into "young" and "old" rats. The radioactivity in urine specimens collected 24 and 48 hours after injection, and in kidneys and livers of animals sacrificed two and 14 days after injection, was determined. It was found that at a given level of injection the activity in urine samples or in these organs was the same in both age groups. The exception was that the kidneys of old rats had greater activity than that of young ones 14 days, but not two days, after injection. These results suggest that the agewise difference in the rate of disappearance of radioactivity from kidneys is associated with the renal metabolism or is related to chemical substances capable of binding B₁₂.