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Effects of Prolonged Ingestion of Xylose on Rats

Pharmacology Laboratory, Bureau of Agricultural and Industrial Chemistry, Agricultural Research Administration, U. S. Department of Agriculture, Albany, California

Xylose was fed for periods up to 140 days to rats at various levels from zero to 25% of the diet. Thirty-five per cent of xylose was fed for short periods. In weanling rats, a level of 15% or more was found to produce lens opacities, which regressed to a considerable degree with time whether or not the animals were continued on the experimental diet. The regression was never complete. Other toxic symptoms observed were diarrhea, bloating, and liver changes suggestive of storage. A voluntary restriction of utilizable food by the xylose-fed rats led to decreased rates of growth. Rats rendered diabetic with alloxan experienced more severe lens opacities when fed xylose than did diabetic controls. Pending more favorable experimental data at lower levels of intake, it is deemed inadvisable to risk the incorporation of xylose in foods at any level of intake for extended periods of time.