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Department of Physiology, Emory University School of Dentistry, Emory University, Georgia, and Research Laboratories, Harvard School of Dental Medicine, Boston, Mass.
Albino rats of the Wistar strain developed no carious lesions when they were fed entirely by stomach tube a high sucrose diet which had previously been shown to be cariogenic when ingested orally.
When all the components of this food mixture except sugar were fed by stomach tube and granulated sugar was ingested orally, the animals having been desalivated for the greater part of the experiment, there developed an appreciable number of carious areas and an appreciable caries score.
When, under the same experimental conditions, sugar was ingested in a 40% aqueous solution, the number of carious areas and the caries score were markedly less than when the same amount of sugar was eaten in the solid form. More than half of the rats were entirely caries-free.
Sugar in solution was therefore found in these experiments to be much less cariogenic than granulated sugar.
Manuscript received 2 September 1952.
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