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Folic Acid Deficiency in the Duck¹

Ten Figures

Department of Nutrition, Harvard School of Public Health, and Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts

Folic acid deficiency has been produced in ducklings and is characterized by reduced growth rate, only slightly reduced food consumption, macrocytic anemia, enlarged liver, and a lowered titer of trypsin and amylase activity in the duodenal contents. The liver from the deficient bird is low in glycogen and slightly high in fat and in total nitrogen content. Blood glucose is normal. Under the experimental conditions employed, no interrelationship was found between folic acid and vitamin B₁₂.

Histopathological examination of deficient tissue showed absence of the secretory cycle of zymogen granules in the pancreas, decreased alkaline phosphatase in the liver, and blurring of striation in the heart.

² Part of the data is from a thesis submitted to the Faculty of the Graduate School of Arts and Sciences, Harvard University, in partial fulfillment of the requirements for the degree of Doctor of Philosophy. Present address: Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.

³ This work was accomplished during the tenure of a research fellowship of the American Heart Association. Present address: University of Pittsburgh School of Public Health, Pittsburgh, Pa.

Manuscript received 11 July 1952.