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Chronic Sodium Chloride Toxicity in the Albino Rat

I. Growth on a Purified Diet Containing Various Levels of Sodium Chloride

Radioisotope Unit and Research Laboratory, Thayer Veterans Administration Hospital, and the Departments of Medicine and Biochemistry, Vanderbilt University School of Medicine Nashville, Tennessee

Young male rats have been raised on a purified diet, containing 7 different levels of sodium chloride, and water ad libitum with the following results:

Rats fed diets high (2.8 to 9.8%) and low (0.01%) in sodium chloride grew more slowly than did rats on a control ration (0.15% NaCl).

High sodium chloride feeding caused polydipsia and polyuria but did not have a marked effect on appetite. A low-sodium diet caused mild anorexia.

Edema developed during this first 20-week period in 10% of the rats fed diets containing from 7.0 to 9.8% of sodium chloride. The majority of the animals (89%) remained in excellent health throughout the 20 weeks.