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Journal of Nutrition Vol. 48 No. 3 November 1952, pp. 369-376
Copyright © 1952 by American Society for Nutrition
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Fate of Lycopene in the Rat and its Effects on the Utilization of Carotene and Vitamin A1

Edward G. High2 and Harry G. Day

Department of Chemistry, Indiana University, Bloomington

Relatively small amounts of lycopene fed with either carotene or vitamin A to vitamin A-depleted rats increased the utilization of both of the latter substances for tissue deposition of vitamin A. Large amounts of lycopene increased vitamin A deposition in vitamin A-fed rats but were without effect on vitamin A deposition from carotene. Lycopene was absorbed and deposited in the livers of rats in approximately 2–6% of the total amount ingested. No lycopene was detected in the kidneys.

1 Contribution 555 from the Department of Chemistry, Indiana University, Bloomington. Supported in part by grants from the Nutrition Foundation, Inc., and the Research Funds of the Graduate School of Indiana University. Some of the data are taken from a thesis submitted by Edward G. High to the Faculty of the Graduate School in partial fulfillment of the requirements for the Ph.D. degree, December, 1949. Presented in part at the 117th Meeting of the American Chemical Society in Houston, Texas, March, 1950.

2 National Institutes of Health Predoctorate Research Fellow, U. S. Public Health Service. Present address: Prairie View Agricultural and Mechanical College, Prairie View, Texas.

Revision accepted 21 July 1952.






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