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Factors Affecting the Development of Acrodynia in Pyridoxine-Deficient Rats

Department of Public Health Nutrition, University of Toronto, Toronto, Canada

Several factors have been noted during investigations with pyridoxine which affect the development of the external deficiency sign, acrodynia.

1. Rats maintained on a diet containing gelatin as the source of nitrogen do not exhibit acrodynia when deprived of pyridoxine and provided with desoxypyridoxine, even when this diet is supplemented with tryptophan, glutamic acid, methionine, and histidine.

2. Supplementation of a diet containing casein with glutamic acid appears to provoke the development of acrodynia in pyridoxine-deficient rats.

3. The inclusion of corn oil in a fat-free, pyridoxine-free diet had no effect upon the rate of appearance of acrodynia, but did appear to prevent the development of a severe stage of the external deficiency sign.

4. In all of the groups studied the appearance of acrodynia was more frequent and more severe in male rats than in the females.

5. Adrenalectomy appeared to prevent the appearance of acrodynia, whereas ovariectomy, ACTH administration and adrenal cortical extract administration were without effect. Administration of a growth hormone preparation appeared to aggravate a pyridoxine deficiency.