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The Effect of Testosterone Propionate on Niacin Metabolism in Rats

Edsel B. Ford Institute for Medical Research, Henry Ford Hospital, Detroit, Michigan

1. Prolonged reduction of N¹-methylnicotinamide excretion was observed in 4-month-old female rats which received 0.5 mg of testosterone propionate intramuscularly daily.

2. When the daily dose of the hormone was increased to 6.25 mg, excretion of the niacin metabolite fell at first, but subsequently rose to about twice the control value.

3. In the kidney, the concentration of coenzymes I and II was unaltered by injecting daily, for 10 days, 0.5-mg or 6.25-mg doses of testosterone propionate, the increase in total amount of the coenzymes being proportional to the increase in organ weight produced by the hormone.

4. In the liver, both dose levels of testosterone propionate increased the concentration of coenzymes I and II, as well as organ weight. The increase in the total amount of these coenzymes in liver was therefore large, being 42% and 64%, respectively, after 0.5-mg and 6.25-mg daily doses.

5. The assumption that diminshed conversion to N¹-methylnicotinamide provided the niacin required for increased synthesis of coenzymes was tenable in some experiments but not in others.

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				W. G. UNGLAUB, G. A. GOLDSMITH, and J. GIBBENS RECENT ADVANCES IN NUTRITION AND METABOLISM: II. Review of the Literature on Vitamins, 1952 Arch Intern Med, October 1, 1954; 94(4): 618 - 647. [Abstract] [PDF]