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The Domestic Cat as a Laboratory Animal for Experimental Nutrition Studies

III. Niacin Requirements and Tryptophan Metabolism

Department of Physiology Faouldade de Medicina, Universidade de São Paulo, ^,2, São Paulo, Brazil

Niacin deficiency, characterized by loss in body weight, diarrhea and death, has been produced in cats fed a 35% casein diet.

Doses of 1 to 3 mg of niacin are effective against the deficiency; the optimum appears to be 10 mg or more. Tryptophan supplements are not effective either in promoting growth or in bringing about urinary excretion of N¹-methyl-nicotinamide. Cats deficient in pyridoxine do not excrete xanthurenic acid following supplementation with tryptophan.

It is concluded that in the cat the metabolism of tryptophan is different from that in other species, at least from the kynurenine stage onward.

² Head: Professor Franklin A. de Moura Campos.

Manuscript received 8 November 1951.

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