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The Relative Utilization of Alpha-Tocopherol and Alpha-Tocopheryl Acetate by Humans

Erling F. Week, Frank J. Sevigne and Marie E. Ellis

Research Laboratory, Collett-Week-Nibecker, Inc., South San Francisco, California

Equivalent, high level dosages of dl-alpha-tocopherol and dl-alpha-tocopheryl acetate were given at suitable intervals to 20 subjects. A series of blood samples were taken and assayed for tocopherol content. The relative utilization of the two forms was determined, using the area between the blood persistence curve and the normal blood level as a measure of absorption.

The utilization of the free alpha-tocopherol was found to be significantly (5% level) superior to the utilization of the alphatocopheryl ester. The mean value for the free form was 35% greater than the mean value for the ester.

Manuscript received 1 October 1951.




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