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Dietary Factors Affecting Gastric Secretion in the Rat

Two Figures

National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, Federal Security Agency, Bethesda, Maryland

Rats maintained on a stock diet secreted larger volumes of gastric juice in 6 hours following pylorus ligation than did those on a "complete" purified diet. The difference was relatively greater in animals maintained on the diets for longer periods of time. The inclusion of certain wheat products or meat meal in the purified diet increased the volume of secretion, although not up to the stock diet level. These findings suggest that the purified diet was deficient in some factor or factors affecting gastric secretion.

Volume of secretion per unit of body surface area is a more satisfactory expression than is volume per unit of body weight for the comparison of gastric secretory performance in pylorus-ligated rats over a wide age-size range.