Journal of Nutrition

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Journal of Nutrition Vol. 46 No. 1 January 1952, pp. 75-85
Copyright © 1952 by American Society for Nutrition
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Niacin Deficiency in the Rhesus Monkey1

Two Figures

D. V. Tappan, U. J. Lewis, U. D. Register and C. A. Elvehjem

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

Rhesus monkeys receiving a niacin-deficient, purified diet containing 9% casein lose weight and develop lowered hemoglobin values after periods of several months.

Tryptophan has been shown capable of replacing the dietary niacin required by monkeys. A very inefficient conversion of tryptophan to niacin, however, occurs in this species.

The niacin requirements of monkeys receiving various diets are discussed.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by a grant from the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation. We are indebted to Merck and Company, Inc., Rahway, New Jersey, for some of the crystalline vitamins.

Manuscript received 10 August 1951.




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