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The Specific Effect of Niacin on Growth¹

Department of Agricultural Chemistry, University of Arkansas, Fayetteville

A modified procedure has been developed for the production of niacin deficiency per se in the albino rat, by incorporating 2% sulfathalidine in a low-casein, corn-containing ration supplemented with an adequate vitamin B complex mixture which furnishes 10 µg folic acid per animal per day. On such dietary regime, which prevents the bacterial synthesis of niacin, and after two weeks of vitamin B complex depletion and a subsequent 12 days of niacin depletion, paired feeding experiments were conducted on 10 pairs of male and 10 pairs of female rats, in which a litter mate of the same sex was given the same amount of food as that consumed by the niacin-deficient animal. The niacin-supplemented animals, which received 100 µg of this vitamin daily, in the course of 10 to 12 weeks gained an average of 93% more in body weight than did the niacin-deficient rats, which we believe represents a specific effect of niacin addition.

Manuscript received 20 August 1951.