QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Smith, S. C. Articles by Elvehjem, C. A. Search for Related Content PubMed PubMed Citation Articles by Smith, S. C. Articles by Elvehjem, C. A.

Further Studies on the Monkey Anti-Anemia Factor Deficiency Produced by Riboflavin Deficiency¹

Two Figures

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

Young rhesus monkeys fed a purified diet deficient in riboflavin developed a condition which did not respond completely to riboflavin therapy. The initial improvement was followed by a period of suboptimum growth and blood picture. This syndrome, characteristic of a lack of the MAAF, was alleviated by PGA at a level 10 times the minimum daily requirement of the normal monkey. A methanol extract of liver of very low PGA content was likewise effective.

It is suggested that the efficacy of the liver extract was due to its content of the MAAF, and that of the PGA is attributed to its favorable influence on the intestinal flora which produce this factor.

Manuscript received 22 June 1951.