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Leucine and Histidine Tolerance in the Human¹

Two Figures

The School of Nutrition and the New York State College of Home Economics, Cornell University, Ithaca

Seven human subjects were fed various amounts of L-leucine or L-histidine dissolved in 500 ml of water. Blood and urine samples, collected for the fasting period and at intervals up to 4 hours after administration of the test solutions, were analyzed for amino acids by microbiological methods.

Leucine ingestion resulted in a rapid rise in plasma leucine, followed by a relatively rapid decline. The leucine content of the red blood cells paralleled the leucine content of the plasma. The amount of leucine recovered in the urine over a 4-hour period did not exceed 0.1%.

The ingestion of histidine caused the plasma histidine to rise, remain elevated for varying lengths of time, and then decline. The histidine content of the red blood cells became elevated but showed only a slight tendency to return to fasting levels during the 4 hours of the test period. The amount of histidine recovered in the urine ranged from 0.3 to 3.8%.

Renal clearances for leucine ranged from 0.2 to 1 ml; for histidine, from 3 to 14 ml.

The assistance of Marie L. Skellinger in part of the work is gratefully acknowledged.

Manuscript received 21 May 1951.

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