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The Lipotropic Effect of Vitamin B₁₂ in the Dog¹

One Figure

Department of Biochemistry of the New York State Medical Center at Syracuse and the Department of Foods and Nutrition, College of Home Economics, Syracuse University, Syracuse, N. Y.

1. A deficiency of vitamin B₁₂ is reported in weanling puppies fed on a synthetic diet containing 19% purified casein and 9% fat. The deficiency varied in severity with different litters of animals and was evident in growth impairment, abnormalities of liver function and, in several instances, gross fatty infiltration of the liver.

2. Administration of either vitamin B₁₂ or choline produced significant improvement in liver function in 4 dogs receiving the basal diet. Two dogs receiving a choline-deficient diet were cured of their fatty livers with vitamin B₁₂ alone.

3. These findings suggest that the dog’s requirement for methylating substances, like that of the rat and chick, is dependent upon the vitamin B₁₂ content of the ration.

Manuscript received 14 March 1951.

This article has been cited by other articles:

				G. A. GOLDSMITH, W. G. UNGLAUB, and J. GIBBENS RECENT ADVANCES IN NUTRITION AND METABOLISM: Review of the Literature, 1951 Arch Intern Med, October 1, 1952; 90(4): 513 - 561. [Abstract] [PDF]