Journal of Nutrition

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Journal of Nutrition Vol. 43 No. 4 April 1951, pp. 525-531
Copyright © 1951 by American Society for Nutrition
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The Influence of Folic Acid, Vitamin B12, and Methyl Donors on White Blood Cell Production in Rats1

James S. Dinning, Lou Dewees Payne and Paul L. Day

Department of Biochemistry, School of Medicine, University of Arkansas, Little Rock

Weanling Sprague-Dawley rats were given a basal methionine-deficient, purified diet. Various groups received this diet with supplements of methionine, choline, or betaine, with and without folic acid and vitamin B12. Rats receiving the basal diet alone developed leucopenia. The leucopenia was prevented by supplements of methionine with or without folic acid and vitamin B12, or by choline or betaine with supplements of folic acid and vitamin B12. Supplements of choline or betaine in the absence of added folic acid and vitamin B12 failed to prevent leucopenia.

1 Research paper No. 952, Journal Series, University of Arkansas. This investigation was supported in part by a research grant from the National Institutes of Health, Public Health Service. The folic acid (pteroylglutamic acid) was supplied by the Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York, and the vitamin B12 (Rubramin) by E. R. Squibb and Sons, New York.

Manuscript received 5 January 1951.


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J. S. Dinning, L. D. Seager, L. D. Payne, and J. R. Totter
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