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Journal of Nutrition Vol. 43 No. 2 February 1951, pp. 193-200
Copyright © 1951 by American Society for Nutrition
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Histologic Bioassay of 3-Methyl-L-Ascorbic Acid

Six Figures

Henry M. Goldman and Bernard S. Gould

Laboratories of Oral Pathology, Beth Israel Hospital, Boston, and Department of Biology, Massachusetts Institute of Technology, Cambridge

Histologic and enzymatic (phosphatase) data are presented to show that 3-methyl-l-ascorbic acid is unquestionably antiscorbutic but that the activity is, by histologic bioassay, definitely less than one-twenty-fifth of the activity of l-ascorbic acid and, on the basis of the phosphatase bioassay, in the order of about one-fiftieth of the activity of l-ascorbic acid.

There is no apparent competitive action between the metabolism of l-ascorbic acid and that of 3-methyl-l-ascorbic acid.

Manuscript received 21 September 1950.




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