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Journal of Nutrition Vol. 42 No. 4 December 1950, pp. 609-618
Copyright © 1950 by American Society for Nutrition
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The Sodium and Potassium Requirements of the Rat for Growth1

Three Figures

R. R. Grunert, James H. Meyer and Paul H. Phillips

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

The sodium and potassium requirements of the rat for growth have been investigated, with the following results:

The growth requirement of the rat for sodium was 0.05% and it was independent of the potassium content within limits of 0.25 to 1.0% potassium.

The potassium requirement was 0.18% in the presence of 0.1% sodium. A high level of sodium (1.0%) reduced the potassium requirement to 0.15%. An initial sparing action by sodium was exhibited provided a minimum amount of potassium was present in the ration. When the potassium was present at less than 0.09%, the initial sparing action of sodium not only disappeared but a potassium deficiency resulted.

It was found that the potassium requirement decreased progressively with increase in age during the 6-week growing period. In contrast, the sodium requirement remained relatively constant throughout the experimental period. One per cent potassium had a growth depressing effect. This was not observed in the case of sodium fed at a 1.0% level.


1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. This work was supported in part by a grant from the American Salt Manufacturers' Association.

Manuscript received 22 August 1950.


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T. Kurtz and R. Morris Jr
Hypertension in the recently weaned Dahl salt-sensitive rat despite a diet deficient in sodium chloride
Science, November 15, 1985; 230(4727): 808 - 810.
[Abstract] [PDF]




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