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The Nitrogen-Sparing Effect of Dietary Carbohydrate in Its Relation to the Time Factor. Experiments with Repletion of Protein-Depleted Adult Rats¹

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Departments of Pharmacology and Physiology, Medical School, University of Southern California, Los Angeles, and the Van Camp Seafood Company, Terminal Island, California

1. Using protein-depleted adult rats, the effect of the time factor in the feeding of protein and carbohydrate has been investigated. It was found that the N retention and growth of the rats which received protein and sugar simultaneously were in all cases considerably higher than those of the rats which received these two food substances separately.

2. The protein-sparing and growth-promoting effects of simultaneous feeding have been demonstrated for a period of 14 days.

3. The biological significance of these results is discussed.

Manuscript received 12 July 1950.