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Journal of Nutrition Vol. 42 No. 3 November 1950, pp. 433-441
Copyright © 1950 by American Society for Nutrition
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An Unidentified Factor Present in Hog Intestinal Mucosa Required by the Mink1

Two Figures

S. B. Tove2, R. J. Lalor and C. A. Elvehjem

Department of Biochemistry, University of Wisconsin, Madison

1. Loss of weight, anorexia, matted fur and death will occur in mink receiving a purified ration supplemented with liver. Autopsy of these animals reveals fatty degeneration of the liver, kidneys and myocardium. Occasionally enlargement of the right side of the heart and atrophy of the adrenal cortex are also observed.
2. A heat labile factor present in desiccated hog intestinal mucosa cures the syndrome of this deficiency and increases the survival time of the mink on experiment.
3. Preliminary evidence indicates that another factor present in fresh spleen and fresh liver is also required.
4. Neither of these factors is identical with the previously reported methanol extract and residue factors.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. These studies were supported by project 614 of the Wisconsin Agricultural Experiment Station, and by grants from the Borden Company, New York, New York, and Fur Farm Food and Supplies, St. Paul, Minnesota. The work was reported briefly in Fed. Proc., 9, 373, 1950.

2 Present address, Animal Nutrition Section, Department of Animal Industry, North Carolina State College, Raleigh.

Manuscript received 12 July 1950.




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