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Journal of Nutrition Vol. 42 No. 1 September 1950, pp. 71-80
Copyright © 1950 by American Society for Nutrition
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The Excretion of Amino Acids in Normal and Undernourished Human Subjects Following a Single Infusion of an Amino Acid Preparation1

One Figure

Stanley Levey, Ellen D. Hoganson, John E. Harroun and Charley J. Smyth2

Department of Physiological Chemistry, Wayne University College of Medicine, Detroit and Wayne County General Hospital, Eloise, Michigan

The excretion of 9 amino acids (arginine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine and valine) was determined in the urine of 4 normal and 4 undernourished subjects after the intravenous infusion of both physiological saline and an assayed amino acid mixture. The degree of undernutrition in the subjects ranged from mild to severe.

No difference was found in either the excretion of the individual amino acids or the total excretion pattern which could be attributed to the nutritional state of the subjects. Both groups retained approximately the same percentage of each of the administered amino acids.

1 Supported in part by a grant from Merck and Company. A preliminary report of this work was presented at the meeting of the American Institute of Nutrition, Atlantic City, April 17–21, 1950.

2 Present address: University of Colorado Medical School, Denver.

Manuscript received 5 May 1950.




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