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Journal of Nutrition Vol. 42 No. 1 September 1950, pp. 31-44
Copyright © 1950 by American Society for Nutrition
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Observations on an Unknown Dietary Factor Essential for Human Growth1

Eleven Figures

Selma E. Snyderman, L. Emmett Holt, Jr., Rosa Lee Nemir, Loren P. Guy, Rosario Carretero2 and Katherine C. Ketron

Department of Pediatrics, School of Medicine, New York University-Bellevue Medical Center, New York, N. Y.

A deficiency syndrome which occurs after prolonged feeding of a purified ration in which all the vitamins are supplied as synthetic supplements is described. The syndrome consists of a cessation of weight gain unaccompanied by any other symptoms or signs. A normal infant diet brings about an immediate weight gain; supplementation with brewers' yeast also has a beneficial effect after a preliminary lag period of 10 to 28 days.

The existence of an unknown factor contained in the normal diet and necessary for human growth has been recognized. This factor may be identical with vitamin B12 or the "animal growth factor"; whether or not it is, remains to be seen.


1 This study was aided by grants from the American Dairy Association, the Sugar Research Foundation, and the Dazian Foundation for Medical Research.

2 Mead Johnson fellow in pediatrics.

Manuscript received 13 June 1949.





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