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Contributions of Brewers' Yeast to a diet Deficient in Reproductive Factors¹

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

Nine brewers' yeasts, including one depurinated yeast, tested as supplements to a basal yellow corn-soybean oil meal-alfalfa ration for rats, failed to furnish the factor or factors needed for successful reproduction and lactation. Fresh beef liver at 5 to 10% of the ration and 5% fish solubles furnished the required factor or factors. In the relatively few animals used, vitamin B₁₂ fed at a level similar to that of the B₁₂ content of 5% fish solubles, or injected subcutaneously at one-half the oral dose, supported reproduction and lactation performances in rats equal to those given by 5% fish solubles under the conditions of these experiments. This suggests that the reproduction and lactation factor in fish solubles may well be vitamin B₁₂.

Manuscript received 10 April 1950.