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Journal of Nutrition Vol. 41 No. 4 August 1950, pp. 507-521
Copyright © 1950 by American Society for Nutrition
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Chronic Essential Fatty Acid Deficiency in Mice1

Five Figures

Arthur B. Decker, Dorothy L. Fillerup and James F. Mead

School of Medicine, University of California at Los Angeles

It has been shown that a state of chronic essential fatty acid deficiency may be produced in mature mice. In this state the external appearance is normal, but typical acute EFA deficiency symptoms, and possibly death, may be produced by the following stresses:

(1) Injuries (even minor); (2) pregnancy (the chronic EFA-deficient females are sterile); (3) x-irradiation.

1 This paper is based on work performed under Contract AT-04-1-GEN-12 between the Atomic Energy Commission and the University of California at Los Angeles.

Manuscript received 3 April 1950.




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