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Journal of Nutrition Vol. 41 No. 3 July 1950, pp. 447-457
Copyright © 1950 by American Society for Nutrition
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Observations on Niacin, Riboflavin, Allantoin, Ascorbic Acid, and Vitamin A during Anabolism Induced by Hormones1

William T. Beher and O. H. Gaebler

Edsel B. Ford Institute for Medical Research, Henry Ford HOspital, and the Department of Chemistry, Wayne University, Detroit, Michigan

1. In adult bitches the excretion of N1-methylnicotinamide decreases markedly during periods of anabolism induced by anterior pituitary growth preparations or testosterone propionate.
2. Coenzymes I and II in the red blood cells do not increase during this apparent storage of niacin.
3. Riboflavin output also decreases following administration of testosterone propionate.
4. Decreases in the excretion of ascorbic acid during similar experiments were significant but less striking; blood ascorbic acid was unchanged.
5. In a single experiment, the concentration of vitamin A in blood fell during the period when testosterone propionate produced its effect.
6. Allantoin excretion remained unchanged in these experiments.
7. The increase in vitamin requirements during normal growth may also be demonstrable during induced growth.

1 The data in this paper are taken from a thesis submitted by one of us (W. T. B.) to the Graduate Council of Wayne University in partial fulfillment of requirements for the degree of Doctor of Philosophy in Chemistry.

Manuscript received 7 February 1950.


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RECENT ADVANCES IN NUTRITION AND METABOLISM: II. Review of the Literature on Vitamins, 1952
Arch Intern Med, October 1, 1954; 94(4): 618 - 647.
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