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Manganese Deficiency in Rats with Relation to Ataxia and Loss of Equilibrium¹

Two Figures

Departments of Biochemistry, Anatomy, and Pathology, University of Colorado Medical Center, Denver

1. Rats have been raised through 4 generations on a diet otherwise adequate but supplying only 0.03 mg of manganese per day to an adult rat.

2. After the first generation several animals of each generation developed symptoms of ataxia and disturbance in equilibrium which appeared earlier in each successive generation. Slight stimuli greatly exaggerated these symptoms.

3. Serial sections of the temporal bones and brains of these animals, stained with hematoxylin and eosin and according to the method of Weil ('28), failed to reveal any lesions that might be responsible for the symptoms. The presence of a chemical lesion in these areas due to the manganese deficiency is suggested.

A preliminary report of this work, with motion pictures, was presented at the meeting of the Federation of American Societies for Experimental Biology in Detroit, April, 1949 (Hill, Holtkamp, Buchanan and Rutledge, '49).

Manuscript received 9 February 1950.