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The Effect of Diet on the Susceptibility of Rats to Poisoning by 2, 4, 6-Trinitrotoluene (TNT)¹

Two Figures

Division of Industrial Hygiene, School of Public Health, Columbia University, New York, N. Y.

1. Observations have been made of the influence of dietary variations in protein, fat and carbohydrate on the toxicity of 2, 4, 6-trinitrotoluene (TNT).

2. TNT in the amounts fed depressed growth irrespective of the type of diet ingested. On the basis of these comparative growth studies it is concluded that a high fat intake does not appear to increase susceptibility to TNT to any marked degree.

3. No differences were noted in the effect of TNT toxicity (using growth as the criterion) when three different fats (corn oil, hydrogenated cottonseed oil, and lard) were used.

4. On the diets containing adequate protein, TNT-fed rats as well as controls grew appreciably better than on the low protein diets. The comparative growth data suggest that protein exerts no specific detoxicating effect on TNT.

5. The type of diet did not influence the hemoglobin levels of the TNT-treated animals, since all of the TNT-treated groups had an anemia of about the same severity.

6. The concentration of the red urinary pigment which was excreted following TNT injection was greater in the urine of rats on the moderate protein-high fat diet than on the other three diets, which did not differ significantly among themselves.

Manuscript received 5 January 1950.