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Journal of Nutrition Vol. 41 No. 2 June 1950, pp. 247-264
Copyright © 1950 by American Society for Nutrition
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Correlation of Urinary Excretion of Riboflavin with Dietary Intake and Symptoms of Ariboflavinosis1

M. K. Horwitt, C. C. Harvey, O. W. Hills2 and E. Liebert

Biochemical Research Laboratory, Elgin State Hospital, Elgin, Illinois

Studies of urinary excretion were made at levels of dietary intake of 0.55, 0.75, 0.85, 1.1, 1.6, 2.15, 2.55 and 3.55 mg per day. Data were recorded on 24-hour urine samples and on samples obtained during the 4 hours after subcutaneous administration of 1 mg of riboflavin. The results obtained by both techniques parallel each other.

Subjects exposed to little or no trauma or irritation and receiving 1.6 mg of riboflavin per day excreted 4 times as much riboflavin as those on a 1.1-mg intake. This suggests that the critical riboflavin requirement for an adult male subsisting on 2,200 calories is somewhere between 1.1 and 1.6 mg of riboflavin per day.

Healing of the skin lesions characteristic of ariboflavinosis is retarded when the 24-hour urinary excretion of riboflavin is less than 50 µg. Such a level may be reached in less than 4 months on a diet containing 0.55 mg of riboflavin per day.

A subject depleted in riboflavin can satisfactorily assimilate at least 6 mg of riboflavin at one time. This was borne out by results which indicated that three 2-mg doses at 4-hour intervals were not more effective in repleting a deficient subject than a single dose of 6 mg of riboflavin in 24 hours.

A period of approximately 15 days is required to saturate riboflavin-depleted subjects when a daily supplement of 6 mg of riboflavin is administered.

1 Data obtained during the tenure of grants from The Josiah Macy, Jr., Foundation, The Milbank Memorial Fund, The National Vitamin Foundation and the U.S. Public Health Service. Sponsored by the National Research Council, Food and Nutrition Board, Committee on Vitamin Deficiency Studies at Elgin State Hospital: Dr. R. M. Wilder, Chairman; Dr. E. S. G. Barron, Dr. C. A. Elvehjem, Dr. M. K. Horwitt, Dr. A. C. Ivy, Dr. E. Liebert, Dr. D. L. Steinberg, Dr. D. Vail and Dr. Ray D. Williams.

2 U.S. Public Health Service Senior Feloow, 1947.

Manuscript received 27 December 1949.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
H. J Powers
Riboflavin (vitamin B-2) and health
Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1352 - 1360.
[Abstract] [Full Text] [PDF]


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