QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kligler, D. Articles by Krehl, W. A. Search for Related Content PubMed PubMed Citation Articles by Kligler, D. Articles by Krehl, W. A.

Lysine Deficiency in Rats

I. Studies with Zein Diets¹

Four Figures

Yale Nutrition Laboratory, Department of Physiological Chemistry, Yale University, New Haven, Connecticut

1. Zein, even when supplemented to theoretically adequate levels with the essential amino acids it does not contain and fed in an otherwise adequate diet, does not promote optimum growth in young rats.

2. Experiments were undertaken in which zein was further supplemented with essential amino acids. The simultaneous addition of arginine, threonine, and valine resulted in a good, though not maximum, growth response.

3. Similarly, when threonine, valine, and arginine were added together to a proteolytic digest of zein, a fair growth response was obtained.

4. These results appear to support the hypothesis that zein is not adequately digested by the growing rat, and that consequently, even when supplemented with a variety of pure amino acids, it does not support a maximum growth response, since all the amino acids esential for protein synthesis are not made available to the animal at the same time.

Manuscript received 21 December 1949.