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Journal of Nutrition Vol. 40 No. 4 April 1950, pp. 595-604
Copyright © 1950 by American Society for Nutrition
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The Influence of Diet Composition on Vitamin B12 Activity in Mice1

Three Figures

D. K. Bosshardt, Winifred J. Paul and R. H. Barnes

Department of Biochemistry, Medioal Research Division, Sharp and Dohme, Inc., Glenolden, Pennsylvania

Variations in dietary composition with regard to fat, carbohydrate and protein have been shown to have an influence on vitamin B12 activity in the growing mouse.

A decrease in the fat level of the diet intensifies the growth retardation due to a deficiency of vitamin B12. This growth retardation may be partially corrected by the feeding of fat or by the administration of vitamin B12. These effects are intensified by increases in the protein level of the diet.

1 Presented before the American Chemical Society, Atlantic City, September 22, 1949.

Manuscript received 12 November 1949.




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