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Journal of Nutrition Vol. 40 No. 3 March 1950, pp. 393-401
Copyright © 1950 by American Society for Nutrition
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The Prevention of Caries in the Syrian Hamster with Sodium Oxalate1

Robert M. Twedt and F. A. Cajori

Department of Biochemistry, University of Colorado School of Medicine, Denver

Young Syrian hamsters, placed on the high-carbohydrate diet of Keyes, developed carious lesions in the occlusal and interproximal sulci and fossae of their teeth. A greater degree of caries activity was observed in the teeth of male animals than in the teeth of females.

The incorporation of sodium oxalate into the cariogenic diet at a level of 0.5% protected the hamster from caries. Chemical analysis of the tooth substance of the animals protected from caries by ingested oxalate revealed that significant amounts of the oxalate had been incorporated into the teeth. On the basis of these findings, the mechanism of the protective action of oxalate has been discussed.

1 This paper was prepared from the thesis presented by Robert M. Twedt to the Graduate School of the University of Colorado for the M.S. degree, June 1949.

Manuscript received 15 October 1949.




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